Current Studies

IDEA — Investigating Dupilumab’s Effect in Asthma by genotype

Purpose:

In this research study, we want to learn if the study drug Dupixent® (dupilumab) helps to control your asthma. We are particularly interested in understanding if people who have a certain genetic make-up (genotype) will respond better to this treatment. This medication is already approved for treating asthma in people 12 years of age and older.

Eligible Participants:

Individuals 12 years of age and older with asthma and who already take an asthma medication for symptom control (daily inhaler or injections) may be eligible to enroll in the study.

Participation Overview:

The study consists of a one-year treatment period, followed by 6 months of observation. During the 1-year treatment period, we will ask you to come in for a study visit a total of 7 times. We will show you how to self-administer the first injection and you will be asked to give yourself the medication at home every 2 weeks. Half of the participants will receive Dupixent®, the other half will be treated with placebo. We will then follow up by phone and we will ask you to come in twice for a study visit during the observation phase.

Blood will be obtained at 5 time points throughout the study. Lung function testing will be done every time you come for a study appointment. Urine, nasal, and house dust samples will also be collected.

Compensation:

Participants may receive up to $870, study medication, and asthma medication included in the study.

Additional Information

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Radon Asthma Intervention Trial (ROME)

To determine if a radon intervention to reduce radon in the home can help improve asthma

Anyone age 5 and above may qualify.

Compensation provided for time and intervention provided without cost.

CAUSE - Childhood Asthma in Urban Settings

CAUSE - Childhood Asthma in Urban Settings

Purpose: The Childhood Asthma in Urban Settings(CAUSE) network is currently recruiting for THREE studies at Boston Children’s, SICAS3, RACR3, CHEETAH, and PANDA. The CAUSE network focuses on asthma and allergy research.

CHEETAH: Mechanisms Underlying Asthma Symptoms and Exacerbations Across T2 status in children. We are studying if there are different mechanisms in asthma symptoms during asthma exacerbations. Children age 6 17 with asthma are eligible.

RACR3: Registry of Asthma Characterization and Recruitment 3, known as RACR3, is a registry study. Registries collect information about people for reference later. In RACR3, we specifically want to collect information about people who might be eligible to participate in research conducted by the CAUSE network.

SICAS3: School Inner City Asthma Study 3 is looking for healthy volunteers and individuals with asthma of any age living or attending school in the Northeast. This study dispenses environmental monitors to volunteers for 3 days to measure pollutants in the air. Additional Information

PANDA: In the PANDA study, we want to learn if treatment with dupilumab, given along with standard asthma care, makes children less likely to have asthma attacks. Dupilumab is given by injection just under the first layer of your skin. Dupilumab is being studied by the researchers in this study in children aged 6-17 years.

Eligible Participants: Those living in Norfolk, Plymouth, Suffolk, Essex, or Middlesex county in Massachusetts, or Rockingham, Strafford in New Hampshire. Those with asthma and allergies are strongly encouraged to contact, and healthy volunteers are welcome.

Participation Overview: Depends on the study! Reach out to learn more.

Compensation: Participation is reimbursed through Target and Visa gift cards for guardians and participants. Total compensation depends on the study, reach out for more information!

School Inner-City Asthma Study

We are looking for school children and adults with asthma and healthy controls for 2 visits to understand mechanisms of asthma and novel pathways to help guide treatment. Compensation provided!

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PARK - Preventing Asthma in High-Risk Kids

Purpose:

Our goal is to study if whether two years of treatment with anti-IgE Xolair® (omalizumab) will prevent progression to asthma and or decrease asthma severity in preschool age, allergic children with a history of wheezing. IgE is critical in allergies and asthma (including food allergies) and this agent blocks this to prevent disease.

Eligible Participants:

Children between the ages of 2 and 4 years who have experiences two to four wheezing/coughing episodes in the last 12 months and have asthma or allergies may be eligible for the study.

Participation Overview:

The participants will receive omalizumab or a placebo during a two-year treatment period. Then the participants will be observed for the following two years. During the treatment period, there will be monthly clinic visits for an injection and surveys to document symptoms and wheezing episodes. During the observation period, monthly phone calls will be conducted to document symptoms and wheezing episodes. Throughout the four years of the study, respiratory medications will be managed by the study team.

Compensation:

Participants who complete the full, four-year trial and observation period will receive up to $2,560 in gift cards. This compensation covers clinic visits, phone calls, parking, and transportation to the clinic. Additionally, asthma rescue medications will be provided at no cost to you.

Additional Information

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